Products

Cas No.Product NameDescription
284461-73-0Sorafenib Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.
1195768-06-9Dabrafenib mesylateDabrafenib is a novel, potent, and selective Raf kinase inhibitor that is capableof inhibiting the kinase activity of wild-type B-Raf, B-RafV600Eand c-Raf with IC50 values of 3.2, 0.8, and 5.0 nM, respectively.
1227678-26-3CEP-32496 hydrochlorideCEP-32496 Hcl is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2.
1228591-30-7/1415800-43-8TAK-632TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity.
1269440-17-6LGX818 LGX818 is an orally available Raf kinase inhibitor with potential antineoplastic activity.
1093100-40-3B-Raf inhibitor 1B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively.
1195765-45-7DabrafenibDabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity.
303727-31-3L-779450L-779450 is a potent, ATP-competitive Raf kinase inhibitor (IC50 =10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.
509093-47-4IRAK-1-4 Inhibitor IIRAK-1-4 Inhibitor I is a IRAK-4 Inhibitor with IC50 of 200 nM, and is an anti-inflammatory agent.
1393466-87-9PLX-8394PLX8394 is a potent and selective inhibitor of B-RafV600E (IC50~5 nM).

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PI3K/Akt/mTOR
Cell Cycle/Checkpoint
Angiogenesis/Tyrosine Kinase
Apoptosis Pathway
PARP/BET
Aurora/Ksp Pathway
MAPK Pathway
Hormone Pathay
Integrase/CCR5
Proteases/HSP90/HSP70 Pathway
Wnt/Hedgehog/Notch Pathway
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Ca/cAMP/Lipid Signaling Pathway
Neuro Signaling Pathway
TGF-beta/Smad Signaling Pathway
GPCR Pathway
Ion channel Pathway
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Intermediate