Cas No.Product NameDescription
879085-55-9Vismodegib Vismodegib is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
1146699-66-2BMS-708163BMS-708163 is a γ-secretase inhibitor (GSI) (IC50 =0.3 nM).
1258861-20-9LY2940680LY2940680 is a potent agent used to treat cancer.
4449-51-8CyclopamineInhibitor of hedgehog signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched.
425386-60-3SemagacestatSemagacestat (LY450139) is a γ-secretase blocker with an IC50 of 15 nM.
284028-89-3XAV-939XAV939 is a small molecule and selective Wnt pathway transcription factor β-catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 of 11 and 4nM for the inhibition of TNKS1 and TNKS2, respectively.
208255-80-5DAPTDAPT is inhibitor of γ-secretase.
847591-62-2ICG-001ICG-001 is a selective Wnt/β-catenin signalling inhibitor with an IC50 of 3μM.
847925-91-1RO4929097RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
471905-41-6MK-0752MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM.
1127442-82-3IWR1-endoIWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
430429-02-0;1127442-87-8IWR-1Act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the β-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b).
6964-62-1NSC 66811Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and MDM2 accumulation in human colon cancer cells in vitro.
500579-04-4GANT61GANT 61 is a small molecule inhibitor of Gli1 and Gli2.
1095173-27-5PF-04449913PF-04449913 is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity.
1427782-89-5 IWP-L6 IWP L6 is a Porcn inhibitor with EC50 of 0.5 nM.
313967-18-9FLI-06FLI-06 is a novel potent and selective small molecule intercepting Notch signaling and the early secretory pathway (EC50 ~2.3 μM), identified by using automated microscopy to monitor the trafficking and processing of a ligand-independent Notch-GFP fusion reporter.
639052-78-1 LH846LH846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2.
1218778-77-8LDE225 Diphosphate/LDE225 Diphosphate (NVP-LDE225; Erismodegib) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
1661839-45-7CCT251545CCT251545 is a potent small-molecule inhibitor of WNT signaling with good oral pharmacokinetics.

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Cell Cycle/Checkpoint
Angiogenesis/Tyrosine Kinase
Apoptosis Pathway
Aurora/Ksp Pathway
MAPK Pathway
Hormone Pathay
Proteases/HSP90/HSP70 Pathway
Wnt/Hedgehog/Notch Pathway
Jak/Stat Pathway
Ca/cAMP/Lipid Signaling Pathway
Neuro Signaling Pathway
TGF-beta/Smad Signaling Pathway
GPCR Pathway
Ion channel Pathway
Cytochrome P450 Pathway
Others Pathway