INCB3344
| CAS No. | 1262238-11-8 | Cat. No. | BCP35107 |
| Name | INCB3344 | ||
| Synonyms | INCB-3344; INCB 3344; | ||
| Formula | C29H34F3N3O6 | M. Wt | 577.59 |
| Description | INCB3344 is a potent and selective antagonist of CCR2 receptor with IC(50) values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. INCB3344 exhibited >100-fold selectivity over other homologous chemokine receptors, a free fraction of 24% in human serum and 15% in mouse serum, and an oral bioavailability of 47% in mice, suitable as a tool compound for target validation in rodent models. | ||
| Pathways | GPCR/G Protein | ||
| Targets | CCR | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.