INCB3344 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1262238-11-8 | Cat. No. | BCP35107 |
| Name | INCB3344 | ||
| Synonyms | INCB-3344; INCB 3344; | ||
| SMILES | CCOC1CN(CC1NC(=O)CNC(=O)C2=CC(=CC=C2)C(F)(F)F)C3CCC(CC3)(C4=CC5=C(C=C4)OCO5)O | ||
| Chemical Name | |||
| Formula | C29H34F3N3O6 | M. Wt | 577.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | INCB3344 is a potent and selective antagonist of CCR2 receptor with IC(50) values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. INCB3344 exhibited >100-fold selectivity over other homologous chemokine receptors, a free fraction of 24% in human serum and 15% in mouse serum, and an oral bioavailability of 47% in mice, suitable as a tool compound for target validation in rodent models. | ||
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