NSC 617145
| CAS No. | 203115-63-3 | Cat. No. | BCP41809 |
| Name | NSC 617145 | ||
| Synonyms | NSC-617145; NSC617145; | ||
| Formula | C13H10Cl4N2O4 | M. Wt | 400.04 |
| Description | NSC-617145 is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. NSC 617145 inhibits growth of HeLa cells via formation of DNA double strand breaks (DSBs) and induction of apoptosis in a WRN helicase-dependent manner. NSC 617145 also acts synergistically with mitomycin C to inhibit growth as well as induce DSBs and chromosomal abnormalities in Fanconia-anemia deficient (FA-D2-/-) cells. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | ATPase | ||
Structure
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