NSC 617145 New
Data Sheet
For research use only. Not for human use.
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|---|---|---|---|
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| CAS No. | 203115-63-3 | Cat. No. | BCP41809 |
| Name | NSC 617145 | ||
| Synonyms | NSC-617145; NSC617145; | ||
| SMILES | CC(C)(CN1C(=O)C(=C(C1=O)Cl)Cl)CN2C(=O)C(=C(C2=O)Cl)Cl | ||
| Chemical Name | |||
| Formula | C13H10Cl4N2O4 | M. Wt | 400.04 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | NSC-617145 is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. NSC 617145 inhibits growth of HeLa cells via formation of DNA double strand breaks (DSBs) and induction of apoptosis in a WRN helicase-dependent manner. NSC 617145 also acts synergistically with mitomycin C to inhibit growth as well as induce DSBs and chromosomal abnormalities in Fanconia-anemia deficient (FA-D2-/-) cells. | ||
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