Merestinib
| CAS No. | 1206799-15-6 | Cat. No. | BCP06826 |
| Name | Merestinib | ||
| Synonyms | LY-2801653;LY 2801653;LY2801653; | ||
| Formula | C30H22F2N6O3 | M. Wt | 552.53 |
| Description | Merestinib, also known as LY2801653, is an orally available, small molecule inhibitor of the proto-oncogene c-Met (mesenchymal-epithelial transition, also known as hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. c-Met inhibitor LY2801653 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. This agent has potent anti-tumor efficacy in mono- and combination therapy in a broad range of cancers. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | c Met | ||
Structure
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