LXR623
| CAS No. | 875787-07-8 | Cat. No. | BCP03659 |
| Name | LXR623 | ||
| Synonyms | LXR-623;LXR 623;WAY-252623;WAY252623;WAY 252623; | ||
| Formula | C21H12ClF5N2 | M. Wt | 422.78 |
| Description | LXR623, also known as WAY-252623, is a highly selective and orally bioavailable synthetic modulator of LXR, which demonstrated efficacy for reducing lesion progression in the murine LDLR(-/-) atherosclerosis model with no associated increase in hepatic lipogenesis either in this model or Syrian hamsters. In nonhuman primates with normal lipid levels, WAY-252623 significantly reduced total (50-55%) and LDL-cholesterol (LDLc) (70-77%) in a time- and dose-dependent manner as well as increased expression of the target genes ABCA1/G1 in peripheral blood cells. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | LXR | ||
Structure
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