LXR623
Data Sheet
For research use only. Not for human use.
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| CAS No. | 875787-07-8 | Cat. No. | BCP03659 |
| Name | LXR623 | ||
| Synonyms | LXR-623;LXR 623;WAY-252623;WAY252623;WAY 252623; | ||
| SMILES | ClC1=C(CN2N=C(C(C(F)(F)F)=CC=C3)C3=C2C4=CC=C(F)C=C4)C=CC(F)=C1 | ||
| Chemical Name | |||
| Formula | C21H12ClF5N2 | M. Wt | 422.78 |
| Purity | 97% | Storage | Store at 4-8°C |
| Description | LXR623, also known as WAY-252623, is a highly selective and orally bioavailable synthetic modulator of LXR, which demonstrated efficacy for reducing lesion progression in the murine LDLR(-/-) atherosclerosis model with no associated increase in hepatic lipogenesis either in this model or Syrian hamsters. In nonhuman primates with normal lipid levels, WAY-252623 significantly reduced total (50-55%) and LDL-cholesterol (LDLc) (70-77%) in a time- and dose-dependent manner as well as increased expression of the target genes ABCA1/G1 in peripheral blood cells. | ||
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