Acrolein
| CAS No. | 4460-86-0 | Cat. No. | BCP02914 |
| Name | Acrolein | ||
| Synonyms | Asaronaldehyde;Asarylaldehyde;NSC 89299;Propenal; | ||
| Formula | C10H12O4 | M. Wt | 196.2 |
| Description | Asaraldehyde is found to be the most abundant constituent, but is totally absent in its cultured broth and its natural host, C. kanehirae wood. On feeding with the acid-digested sawdust of C. kanehirae wood or vanillin to the broth for culture, Asaraldehyde is produced in both cultured broths. Asaraldehyde shows 3.32% of prostaglandin H endoperoxide synthase-1 (COX-1) inhibitory activity and 52.69% prostaglandin H endoperoxide synthase-2 (COX-2) inhibitory activity, respectively at 100 mg/mL. Asaraldehyde shows selectivity towards COX-2 enzyme inhibition at 100 μg/mL. The COX-2/COX-1 ratio for Asaraldehyde is 17.68 at 100 μg/mL compared to solvent control.Asaraldehyde down-regulates C/EBPβ, C/EBPδ, and C/EBPα. Asaraldehyde suppresses expression of PPARγ1 and PPARγ2. Asaraldehyde also significantly suppresses the expression of acetyl-CoA carboxylase (ACC). | ||
| Pathways | Neuro Signaling Pathway | ||
| Targets | COX | ||
Structure
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