LDN-193189
| CAS No. | 1062368-24-4 | Cat. No. | BCP01907 |
| Name | LDN-193189 | ||
| Synonyms | LDN193189;DM3189;LDN 193189;DM 3189;DM-3189; | ||
| Formula | C25H22N6 | M. Wt | 406.48 |
| Description | LDN193189 potently inhibits BMP4-mediated Smad1, Smad5 and Smad8 activation with IC50 of 5 nM, and efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively. Furthermore, LDN193189 also shows the inhibitory effect on the transcriptional activity induced by either constitutively active ALK2R206H or ALK2Q207D mutant proteins. A recent study shows that LDN-193189 blocks the production of reactive oxygen species induced by oxidized LDL during atherogenesis in human aortic endothelial cells. | ||
| Pathways | TGF beta/Smad | ||
| Targets | BMP/TGF beta Receptor | ||
Structure
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