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LDN-193189 Chemical Structure

LDN-193189

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01907CAS No. ：1062368-24-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1062368-24-4 Cat. No. BCP01907
Name LDN-193189
Synonyms LDN193189;DM3189;LDN 193189;DM 3189;DM-3189;
SMILES
Chemical Name
Formula C25H22N6 M. Wt 406.48
Purity 98% Storage Store at 4-8°C
Description LDN193189 potently inhibits BMP4-mediated Smad1, Smad5 and Smad8 activation with IC50 of 5 nM, and efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively. Furthermore, LDN193189 also shows the inhibitory effect on the transcriptional activity induced by either constitutively active ALK2R206H or ALK2Q207D mutant proteins. A recent study shows that LDN-193189 blocks the production of reactive oxygen species induced by oxidized LDL during atherogenesis in human aortic endothelial cells.
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