Aprocitentan
| CAS No. | 1103522-45-7 | Cat. No. | BCP28125 |
| Name | Aprocitentan | ||
| Synonyms | N-Despropyl-macitentan;ACT-132577; ACT 132577; ACT132577; | ||
| Formula | C16H14Br2N6O4S | M. Wt | 546.19 |
| Description | Aprocitentan, also known as ACT-132577, is an endothelin receptor antagonist and an pharmacologically active metabolite of macitentan (MedKoo Cat#205912). Aprocitentan antagonized the specific binding of ET-1 on membranes of cells overexpressing ET(A) and ET(B) receptors and blunted ET-1-induced calcium mobilization in various natural cell lines, with inhibitory constants within the nanomolar range. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Endothelin Receptor | ||
Structure
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