Aprocitentan New
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| CAS No. | 1103522-45-7 | Cat. No. | BCP28125 |
| Name | Aprocitentan | ||
| Synonyms | N-Despropyl-macitentan;ACT-132577; ACT 132577; ACT132577; | ||
| SMILES | O=S(N)(NC1=NC=NC(OCCOC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O | ||
| Chemical Name | |||
| Formula | C16H14Br2N6O4S | M. Wt | 546.19 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Aprocitentan, also known as ACT-132577, is an endothelin receptor antagonist and an pharmacologically active metabolite of macitentan (MedKoo Cat#205912). Aprocitentan antagonized the specific binding of ET-1 on membranes of cells overexpressing ET(A) and ET(B) receptors and blunted ET-1-induced calcium mobilization in various natural cell lines, with inhibitory constants within the nanomolar range. | ||
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