U73343
| CAS No. | 142878-12-4 | Cat. No. | BCP12871 |
| Name | U73343 | ||
| Synonyms | U-73343;U 73343; | ||
| Formula | C29H42N2O3 | M. Wt | 466.66 |
| Description | U-73343 is a negative control (or inactive analogue) of U73122, which is a putative phospholipase C inhibitor. U73343 was found to inhibit TxA2 formation; it therefore partially inhibited the rise in [Ca2+]i evoked by low concentrations of thrombin, by thapsigargin or by collagen. U73343 had a greater effect than aspirin on the action of collagen, indicating an action on the TxA2-independent component of the signal, via PLC gamma-U73343 lowered TxA2 production by inhibiting the activation of cPLA2, probably at a tyrosine phosphorylation step. U73343 seems to inhibit only the tyrosine kinases involved in the activation of PLC gamma and the generation of TxA2. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phospholipase | ||
Structure
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