U73343

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP12871CAS No. ：142878-12-4Purity：98%

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CAS No.	142878-12-4	Cat. No.	BCP12871
Name	U73343
Synonyms	U-73343;U 73343;
SMILES	C[C@]12[C@](CC[C@@H]1NCCCCCCN(C3=O)C(CC3)=O)([H])[C@@]4([H])[C@@](CC2)([H])C(C=CC(OC)=C5)=C5CC4
Chemical Name
Formula	C29H42N2O3	M. Wt	466.66
Purity	98%	Storage	Store at 4-8°C
Description	U-73343 is a negative control (or inactive analogue) of U73122, which is a putative phospholipase C inhibitor. U73343 was found to inhibit TxA2 formation; it therefore partially inhibited the rise in [Ca2+]i evoked by low concentrations of thrombin, by thapsigargin or by collagen. U73343 had a greater effect than aspirin on the action of collagen, indicating an action on the TxA2-independent component of the signal, via PLC gamma-U73343 lowered TxA2 production by inhibiting the activation of cPLA2, probably at a tyrosine phosphorylation step. U73343 seems to inhibit only the tyrosine kinases involved in the activation of PLC gamma and the generation of TxA2.