AZD7986

  • Chemical Properties
CAS No. 1802148-05-5 Cat. No. BCP25020
Name AZD7986
Synonyms AZD-7986; AZD 7986; INS 1007; INS-1007; INS1007.;
Formula C23H24N4O4 M. Wt 420.47
  • Biological Activity
Description AZD7986, also known as INS 1007, is a second generation reversible covalent, potent and selective DPP1 inhibitor potentially for the treatment of chronic obstructive pulmonary disease (COPD) with predicted human PK properties suitable for once daily human dosing. AZD7986 showed pIC50 (DPPI) = 6.85. Good species crossover was seen for compound 30, with the DPP1 enzyme pIC50 values being determined to for mouse 7.6, rat 7.7, dog 7.8, and rabbit 7.8.
Pathways Protease/Metabolic Enzyme 
Targets DPP 

Structure

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