AZD7986
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1802148-05-5 | Cat. No. | BCP25020 |
| Name | AZD7986 | ||
| Synonyms | AZD-7986; AZD 7986; INS 1007; INS-1007; INS1007.; | ||
| SMILES | O=C([C@]1OCCCNC1)N[C@](C#N)CC2=CC=C(C3=CC=C(OC(N4C)=O)C4=C3)C=C2 | ||
| Chemical Name | |||
| Formula | C23H24N4O4 | M. Wt | 420.47 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AZD7986, also known as INS 1007, is a second generation reversible covalent, potent and selective DPP1 inhibitor potentially for the treatment of chronic obstructive pulmonary disease (COPD) with predicted human PK properties suitable for once daily human dosing. AZD7986 showed pIC50 (DPPI) = 6.85. Good species crossover was seen for compound 30, with the DPP1 enzyme pIC50 values being determined to for mouse 7.6, rat 7.7, dog 7.8, and rabbit 7.8. | ||
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