SB218078
| CAS No. | 135897-06-2 | Cat. No. | BCP25033 |
| Name | SB218078 | ||
| Synonyms | SB 218078;SB-218078; | ||
| Formula | C24H15N3O3 | M. Wt | 393.39 |
| Description | SB-218078 is a potent, selective, ATP-competitive and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. SB-218078 is less potently inhibits Cdc2 (IC50 of 250 nM) and PKC (IC50 of 1000 nM). SB-218078 causes apoptosis by DNA damage and cell cycle arrest. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Checkpoint | ||
Structure
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