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SB218078 Chemical Structure

SB218078

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP25033CAS No. ：135897-06-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 135897-06-2 Cat. No. BCP25033
Name SB218078
Synonyms SB 218078;SB-218078;
SMILES C1CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C1O2)C7=C53)C(=O)NC6=O
Chemical Name
Formula C24H15N3O3 M. Wt 393.39
Purity 98% Storage Store at 4-8°C
Description SB-218078 is a potent, selective, ATP-competitive and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. SB-218078 is less potently inhibits Cdc2 (IC50 of 250 nM) and PKC (IC50 of 1000 nM). SB-218078 causes apoptosis by DNA damage and cell cycle arrest.
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