AA269
| CAS No. | 1312782-34-5 | Cat. No. | BCP20643 |
| Name | AA269 | ||
| Synonyms | |||
| Formula | C₇H₁₀N₄O | M. Wt | 166.18 |
| Description | AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme’s serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phospholipase | ||
Structure
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