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AA269 Chemical Structure

AA269

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20643CAS No. :1312782-34-5Purity:98
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  • Chemical Properties&Biological Activity
CAS No. 1312782-34-5 Cat. No. BCP20643
Name AA269
Synonyms
SMILES
Chemical Name
Formula C₇H₁₀N₄O M. Wt 166.18
Purity 98 Storage Store at 4-8°C
Description AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme’s serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells
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