CC-115 (hydrochloride)
| CAS号 | 1300118-55-1 | 货号 | BCP20709 |
| 中文名 | CC-115 (hydrochloride) | ||
| 英文名 | CC-115 (hydrochloride) | ||
| 中文别名 | |||
| 英文别名 | CC-115 (hydrochloride); | ||
| 分子式 | C16H17ClN8O | 分子量 | 372.81 |
| 生物活性 | CC-115 hydrochloride is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). IC50 value: 21 nM (for mTOR), 13 nM (for DNA-PK) Target: mTOR, DNA-PK in vitro: The IC50 values for CC-115 are >10 μM against a panel of CYP enzymes and >33 μM for the hERG ion channel. When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target was inhibited >50% (PDE3, IC50 = 0.63 μM). in vivo: CC-115 shows good PK profiles across multiple species with 53%, 76%, and 100% oral bioavailability in mouse, rat, and dog, respectively. CC-115, with favorable physicochemical and pharmacokinetic properties, demonstrates mTOR pathway inhibition and tumor growth inhibition, as well as a good safety profile, suitable for clinical development. | ||
| 信号通路 | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| 靶 点 | DNA PK mTOR | ||
结构式
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