GSK583
| CAS号 | 1346547-00-9 | 货号 | BCP25523 |
| 中文名 | GSK583 | ||
| 英文名 | GSK583 | ||
| 中文别名 | |||
| 英文别名 | GSK 583; GSK-583; | ||
| 分子式 | C20H19FN4O2S | 分子量 | 398.46 |
| 生物活性 | GSK583 is a selective inhibitor of RIP-like interacting CLARP kinase (RICK also known as RIP2 kinase; IC50 = 5 nM).RIP2 Kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines. In an ex vivo human translational model using intestinal mucosal tissue from inflammatory bowel disease patients, GSK583 inhibited both TNF-α and IL-6 production with an IC50 value of 200 nM. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | RIP | ||
结构式
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