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| CAS号 | 1346547-00-9 | 货号 | BCP25523 |
| 中文名 | GSK583 | ||
| 英文名 | GSK583 | ||
| 中文别名 | |||
| 英文别名 | GSK 583; GSK-583; | ||
| SMILES | FC1=CC2=C(NN=C2NC3=CC=NC4=CC=C(S(=O)(C(C)(C)C)=O)C=C34)C=C1 | ||
| 化学名称 | |||
| 分子式 | C20H19FN4O2S | 分子量 | 398.46 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | GSK583 is a selective inhibitor of RIP-like interacting CLARP kinase (RICK also known as RIP2 kinase; IC50 = 5 nM).RIP2 Kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of inflammatory cytokines. In an ex vivo human translational model using intestinal mucosal tissue from inflammatory bowel disease patients, GSK583 inhibited both TNF-α and IL-6 production with an IC50 value of 200 nM. | ||
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