Cranad 2
| CAS号 | 1193447-34-5 | 货号 | BCP25913 |
| 中文名 | Cranad 2 | ||
| 英文名 | Cranad 2 | ||
| 中文别名 | |||
| 英文别名 | Cranad-2; Cranad2; | ||
| 分子式 | C25H27BF2N2 | 分子量 | 404.31 |
| 生物活性 | Cranad 2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | Amyloid β | ||
结构式
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