Cranad 2 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP25913CAS号：1193447-34-5纯度：98%

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CAS号	1193447-34-5	货号	BCP25913
中文名	Cranad 2
英文名	Cranad 2
中文别名
英文别名	Cranad-2; Cranad2;
SMILES	[B-]1(OC(=CC(=CC=C2C=CC(=[N+](C)C)C=C2)O1)C=CC3=CC=C(C=C3)N(C)C)(F)F
化学名称
分子式	C25H27BF2N2	分子量	404.31
纯度	98%	配送	惯例下常温包邮
产品描述	Cranad 2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield. Moreover, this probe also shows a high affinity for Abeta aggregates (K(d) = 38.0 nM), a reasonable log P value (log P = 3), considerable stability in serum, and a weak interaction with albumin. After intravenous injection of this probe, 19-month-old Tg2576 mice exhibited significantly higher relative signal than that of the control mice over the same period of time.