CFI-400945 fumarate
| CAS号 | 1616420-30-4 | 货号 | BCP25931 |
| 中文名 | CFI-400945 fumarate | ||
| 英文名 | CFI-400945 fumarate | ||
| 中文别名 | |||
| 英文别名 | Ocifisertib Fumarate;CFI400945; CFI 400945; CFI-400945；CFI400945 fumarate; | ||
| 分子式 | C37H38N4O7 | 分子量 | 650.72 |
| 生物活性 | CFI-400945 fumarate is an orally available fumarate salt form of CFI-400945, a polo-like kinase 4 (PLK4) inhibitor with potential antineoplastic activity. Upon oral administration, polo-like kinase 4 inhibitor CFI-400945 selectively inhibits PLK4, which results in the disruption of mitosis and the induction of apoptosis. PLK4 inhibition also prevents cell division and inhibits proliferation of PLK4-overexpressing tumor cells. PLK4, a member of the polo family of serine/threonine kinases overexpressed in a variety of cancer cell types, plays a crucial role in the regulation of centriole duplication during the cell cycle. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | PLK | ||
结构式
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