(Z)-Necrosulfonamide
| CAS No. | 1360614-48-7 | Cat. No. | BCP25934 |
| Name | (Z)-Necrosulfonamide | ||
| Synonyms | (2Z)-N-{4-[(3-Methoxy-2-pyrazinyl)sulfamoyl]phenyl}-3-(5-nitro-2-thienyl)acrylamide; | ||
| Formula | C18H15N5O6S2 | M. Wt | 461.472 |
| Description | Necrosulfonamide is a small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation; binds within the N-terminal 178 residues of human MLKL; arrests necrosis at a specific step at which RIP3 formed discrete punctae in cells. | ||
| Pathways | MAPK Pathway | ||
| Targets | MLK | ||
Structure
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