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(Z)-Necrosulfonamide Chemical Structure

(Z)-Necrosulfonamide

Data Sheet For research use only. Not for human use.
Cat. No. :BCP25934CAS No. :1360614-48-7Purity:
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  • Chemical Properties&Biological Activity
CAS No. 1360614-48-7 Cat. No. BCP25934
Name (Z)-Necrosulfonamide
Synonyms (2Z)-N-{4-[(3-Methoxy-2-pyrazinyl)sulfamoyl]phenyl}-3-(5-nitro-2-thienyl)acrylamide;
SMILES O=C(NC1=CC=C(S(=O)(NC2=NC=CN=C2OC)=O)C=C1)/C=C/C3=CC=C([N+]([O-])=O)S3
Chemical Name
Formula C18H15N5O6S2 M. Wt 461.472
Purity Storage Store at 4-8°C
Description Necrosulfonamide is a small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation; binds within the N-terminal 178 residues of human MLKL; arrests necrosis at a specific step at which RIP3 formed discrete punctae in cells.
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