(Z)-Necrosulfonamide New
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CAS No. | 1360614-48-7 | Cat. No. | BCP25934 |
Name | (Z)-Necrosulfonamide | ||
Synonyms | (2Z)-N-{4-[(3-Methoxy-2-pyrazinyl)sulfamoyl]phenyl}-3-(5-nitro-2-thienyl)acrylamide; | ||
SMILES | O=C(NC1=CC=C(S(=O)(NC2=NC=CN=C2OC)=O)C=C1)/C=C/C3=CC=C([N+]([O-])=O)S3 | ||
Chemical Name | |||
Formula | C18H15N5O6S2 | M. Wt | 461.472 |
Purity | Storage | Store at 4-8°C | |
Description | Necrosulfonamide is a small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation; binds within the N-terminal 178 residues of human MLKL; arrests necrosis at a specific step at which RIP3 formed discrete punctae in cells. |
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