Pocapavir
  • 化学数据
CAS号 146949-21-5 货号 BCP20876
中文名 Pocapavir
英文名 Pocapavir
中文别名
英文别名 SCH-48973; SCH48973; SCH 48973; V074; V 073; V-073;
分子式 C21H17Cl3O3 分子量 423.71
  • 用途
生物活性 Pocapavir, also known as SCH-48973 and V-073, is a potent, selective, antienterovirus agent. SCH-48973 had antiviral activity (50% inhibitory concentrations [IC50s]) of 0.02 to 0.11 microg/ml, with no detectable cytotoxicity at 50 microg/ml. SCH-48973 inhibited 80% of 154 recent human enterovirus isolates at an IC50 of 0.9 microg/ml. The affinity constant (Ki) for SCH-48973 binding to poliovirus was 8.85 x 10(-8) M. SCH-48973 demonstrated efficacy in a murine poliovirus model of enterovirus disease. SCH-48973 represents a potential candidate for therapeutic intervention against enterovirus infections.
信号通路 Microbiology/Virology 
靶 点 Enterovirus 

结构式

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