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CAS号 | 146949-21-5 | 货号 | BCP20876 |
中文名 | Pocapavir | ||
英文名 | Pocapavir | ||
中文别名 | |||
英文别名 | SCH-48973; SCH48973; SCH 48973; V074; V 073; V-073; | ||
SMILES | |||
化学名称 | |||
分子式 | C21H17Cl3O3 | 分子量 | 423.71 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Pocapavir, also known as SCH-48973 and V-073, is a potent, selective, antienterovirus agent. SCH-48973 had antiviral activity (50% inhibitory concentrations [IC50s]) of 0.02 to 0.11 microg/ml, with no detectable cytotoxicity at 50 microg/ml. SCH-48973 inhibited 80% of 154 recent human enterovirus isolates at an IC50 of 0.9 microg/ml. The affinity constant (Ki) for SCH-48973 binding to poliovirus was 8.85 x 10(-8) M. SCH-48973 demonstrated efficacy in a murine poliovirus model of enterovirus disease. SCH-48973 represents a potential candidate for therapeutic intervention against enterovirus infections. |
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