LYN-1604
| CAS号 | 2088939-99-3 | 货号 | BCP28888 |
| 中文名 | LYN-1604 | ||
| 英文名 | LYN-1604 | ||
| 中文别名 | |||
| 英文别名 | LYN 1604; LYN1604; | ||
| 分子式 | C33H43Cl2N3O2 | 分子量 | 584.62 |
| 生物活性 | LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 could induce cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells. To further explore LYN-1604-induced autophagic mechanisms, we found some potential ULK1 interactors, such as ATF3, RAD21, and caspase3, by performing comparative microarray analysis. LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 has potential for good therapeutic effects on TNBC by targeting ULK1-modulated cell death in vivo; thus making this ULK1 agonist a novel potential small-molecule drug candidate for future TNBC therapy. | ||
| 上下游产品 | LYN-1604HLC（LYN-1604 hydrochloride） 2310109-38-5（LYN-1604 dihydrochloride） | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | Autophagy | ||
结构式
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