SAICAR

  • Chemical Properties
CAS No. 3031-95-6 Cat. No. BCP28964
Name SAICAR
Synonyms Succino-AICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5'-phosphate;
Formula C13H19N4O12P M. Wt 454.28
  • Biological Activity
Description SAICAR, also known as Succino-AICAR, is an intermediate in the de novo purine nucleotide synthesis pathway. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. SAICAR-mediated PKM2 protein kinase activity is necessary for EGF-induced cancer cell proliferation.

Structure

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