SAICAR
Data Sheet
For research use only. Not for human use.
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| CAS No. | 3031-95-6 | Cat. No. | BCP28964 |
| Name | SAICAR | ||
| Synonyms | Succino-AICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5'-phosphate; | ||
| SMILES | O=C(O)C[C@@H](C(O)=O)NC(C1=C(N)N([C@H]2[C@@H]([C@@H]([C@@H](COP(O)(O)=O)O2)O)O)C=N1)=O | ||
| Chemical Name | |||
| Formula | C13H19N4O12P | M. Wt | 454.28 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SAICAR, also known as Succino-AICAR, is an intermediate in the de novo purine nucleotide synthesis pathway. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. SAICAR-mediated PKM2 protein kinase activity is necessary for EGF-induced cancer cell proliferation. | ||
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