PF-06260933 dihydrochloride

  • Chemical Properties
CAS No. 1883548-86-4 Cat. No. BCP28969
Name PF-06260933 dihydrochloride
Synonyms PF06260933 dihydrochloride; PF 06260933 dihydrochloride; PF-06260933 2HCl;
Formula C16H15Cl3N4 M. Wt 369.67
  • Biological Activity
Description PF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM; possesses excellent kinome selectivity and suitable properties for in vivo pharmacological characterization; significantly improves fasting hyperglycemia (44% reduction in blood glucose, 10 mg/kg, bid); also markedly reduces atherosclerotic lesion area in mice.
Pathways MAPK Pathway 
Targets MAP4K 

Structure

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