PF-06260933 dihydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1883548-86-4 | Cat. No. | BCP28969 |
| Name | PF-06260933 dihydrochloride | ||
| Synonyms | PF06260933 dihydrochloride; PF 06260933 dihydrochloride; PF-06260933 2HCl; | ||
| SMILES | NC1=CC=C(C2=CC(C3=CC=C(Cl)C=C3)=C(N)N=C2)C=N1.[H]Cl.[H]Cl | ||
| Chemical Name | |||
| Formula | C16H15Cl3N4 | M. Wt | 369.67 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PF 6260933 is a potent, selective and orally bioavailable MAP4K4 inhibitor with kinase IC50 of 3.7 nM, cell IC50 of 160 nM; possesses excellent kinome selectivity and suitable properties for in vivo pharmacological characterization; significantly improves fasting hyperglycemia (44% reduction in blood glucose, 10 mg/kg, bid); also markedly reduces atherosclerotic lesion area in mice. | ||
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