Ensartinib dihydrochloride

CAS No.	2137030-98-7	Cat. No.	BCP29059
Name	Ensartinib dihydrochloride
Synonyms	X396; X-396; X 396;X-396 hydrochloride;
Formula	C26H29Cl4FN6O3	M. Wt	634.36

Description	Ensartinib, also known as X-396, is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development.
Pathways	Angiogenesis/Protein Tyrosine Kinase
Targets	c Met ALK

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