Ensartinib dihydrochloride
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CAS No. | 2137030-98-7 | Cat. No. | BCP29059 |
Name | Ensartinib dihydrochloride | ||
Synonyms | X396; X-396; X 396;X-396 hydrochloride; | ||
SMILES | O=C(C1=NN=C(N)C(O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4C[C@@H](C)N[C@@H](C)C4)=O)C=C3.[2HCl] | ||
Chemical Name | |||
Formula | C26H29Cl4FN6O3 | M. Wt | 634.36 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Ensartinib, also known as X-396, is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. |
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