UM164
| CAS No. | 903564-48-7 | Cat. No. | BCP29207 |
| Name | UM164 | ||
| Synonyms | UM 164;UM-164; | ||
| Formula | C30H31F3N8O3S | M. Wt | 640.69 |
| Description | UM164 is a movel potent, dual c-Src/p38 with Kd of 2.7 nM (c-Src), potently inhibits both p38α and p38β; inhibits c-Src autophosphorylation in TNBC cell lines, and shows potent antiproliferative activity with mean GI50 of 160 nM, alters the cell localization of c-Src in TNBC cells; completely inhibits p38 MAPK phosphorylation in SUM 149 cells at 50 nM; demonstrates potent anti-TNBC activity in xenograft models with limited in vivo toxicity. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase MAPK Pathway | ||
| Targets | Src/Bcr Abl p38 MAPK | ||
Structure
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