UM164
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CAS No. | 903564-48-7 | Cat. No. | BCP29207 |
Name | UM164 | ||
Synonyms | UM 164;UM-164; | ||
SMILES | O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCO)CC3)=C2)S1)NC4=CC(NC(C5=CC=CC(C(F)(F)F)=C5)=O)=CC=C4C | ||
Chemical Name | |||
Formula | C30H31F3N8O3S | M. Wt | 640.69 |
Purity | 98% | Storage | Store at 4-8°C |
Description | UM164 is a movel potent, dual c-Src/p38 with Kd of 2.7 nM (c-Src), potently inhibits both p38α and p38β; inhibits c-Src autophosphorylation in TNBC cell lines, and shows potent antiproliferative activity with mean GI50 of 160 nM, alters the cell localization of c-Src in TNBC cells; completely inhibits p38 MAPK phosphorylation in SUM 149 cells at 50 nM; demonstrates potent anti-TNBC activity in xenograft models with limited in vivo toxicity. |
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