Ketohexokinase inhibitor 1

CAS No.	2102501-84-6	Cat. No.	BCP29373
Name	Ketohexokinase inhibitor 1
Synonyms	PF-06835919;PF06835919;PF 06835919;MDK1846;MDK-1846; MDK 1846;Ketohexokinase-In-1;
Formula	C16H19F3N4O2	M. Wt	356.34

Description	Ketohexokinase inhibitor 1is a potent ketohexokinase (KHK) inhibitor. MDK1846 has CAS#2102501-84-6. The last 4 digit was used for naming for the convenience of scientific communication. MDK1846 is reported in patent US 20170183328 A1, example 4. Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders.
Pathways	Others Pathway
Targets	Others

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