Ketohexokinase inhibitor 1 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2102501-84-6 | Cat. No. | BCP29373 |
| Name | Ketohexokinase inhibitor 1 | ||
| Synonyms | PF-06835919;PF06835919;PF 06835919;MDK1846;MDK-1846; MDK 1846;Ketohexokinase-In-1; | ||
| SMILES | CC1CCN1C2=NC(=CC(=N2)N3CC4C(C3)C4CC(=O)O)C(F)(F)F | ||
| Chemical Name | |||
| Formula | C16H19F3N4O2 | M. Wt | 356.34 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Ketohexokinase inhibitor 1is a potent ketohexokinase (KHK) inhibitor. MDK1846 has CAS#2102501-84-6. The last 4 digit was used for naming for the convenience of scientific communication. MDK1846 is reported in patent US 20170183328 A1, example 4. Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders. | ||
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