BIBN 4096BS

CAS No.	204697-65-4	Cat. No.	BCP29403
Name	BIBN 4096BS
Synonyms	BIBN-4096; BIBN4096; BIBN 4096; BIBN-4096BS; BIBN4096BS; Olcegepant;
Formula	C38H47Br2N9O5	M. Wt	869.65

Description	BIBN 4096BS, also known as BIBN-4096 or Olcegepant is is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor, a key modulator in neurogenic inflammatory pain. In preclinical studies, olcegepant attenuated arterial dilation induced by CGRP or electrical stimulation. In a phase II clinical trial, olcegepant reduced the severity of headache in 60% of migraine sufferers and met secondary endpoints including headache-free rate and rate of sustained response. The compound appears to be an effective anti-migraine medication that is well tolerated and does not display the vasoconstrictive effect that precludes the use of triptans and dihydroergotamine in certain patients.
Pathways	Neuro Signaling Pathway GPCR/G Protein
Targets	CGRP Receptor

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