BIBN 4096BS

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP29403CAS No. ：204697-65-4Purity：98%

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CAS No.	204697-65-4	Cat. No.	BCP29403
Name	BIBN 4096BS
Synonyms	BIBN-4096; BIBN4096; BIBN 4096; BIBN-4096BS; BIBN4096BS; Olcegepant;
SMILES	O=C1N(CC2=C(N1)C=CC=C2)C3CCN(C(N[C@@H](C(N[C@H](C(N4CCN(C5=CC=NC=C5)CC4)=O)CCCCN)=O)CC6=CC(Br)=C(C(Br)=C6)O)=O)CC3
Chemical Name
Formula	C38H47Br2N9O5	M. Wt	869.65
Purity	98%	Storage	Store at 4-8°C
Description	BIBN 4096BS, also known as BIBN-4096 or Olcegepant is is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor, a key modulator in neurogenic inflammatory pain. In preclinical studies, olcegepant attenuated arterial dilation induced by CGRP or electrical stimulation. In a phase II clinical trial, olcegepant reduced the severity of headache in 60% of migraine sufferers and met secondary endpoints including headache-free rate and rate of sustained response. The compound appears to be an effective anti-migraine medication that is well tolerated and does not display the vasoconstrictive effect that precludes the use of triptans and dihydroergotamine in certain patients.