BMS-986142
  • 化学数据
CAS号 1643368-58-4 货号 BCP29622
中文名 BMS-986142
英文名 BMS-986142
中文别名
英文别名 BMS 986142; BMS986142;
分子式 C32H30F2N4O4 分子量 572.61
  • 用途
生物活性 BMS-986142 is a potent, selective, reversible BTK inhibitor. BMS-986142 shows BTK IC50 = 0.5nM; human WB IC50 = 90 nM. In molecule of BMS-986142, two atropisomeric centers were rotationally locked to provide a single, stable atropisomer, resulting in enhanced potency and selectivity as well as a reduction in safety liabilities. With significantly enhanced potency and selectivity, excellent in vivo properties and efficacy, and a very desirable tolerability and safety profile, BMS-986142 was advanced into clinical studies.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 BTK 

结构式

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