DAP-81
| CAS No. | 794466-17-4 | Cat. No. | BCP29728 |
| Name | DAP-81 | ||
| Synonyms | DAP81; DAP 81; | ||
| Formula | C25H20N6O4 | M. Wt | 468.46 |
| Description | DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | PLK | ||
Structure
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