DAP-81
Data Sheet
For research use only. Not for human use.
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| CAS No. | 794466-17-4 | Cat. No. | BCP29728 |
| Name | DAP-81 | ||
| Synonyms | DAP81; DAP 81; | ||
| SMILES | CC(NC1=CC=C(NC2=NC=C([N+]([O-])=O)C(NC3=CC=CC=C3C(C4=CC=CC=C4)=O)=N2)C=C1)=O | ||
| Chemical Name | |||
| Formula | C25H20N6O4 | M. Wt | 468.46 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations. | ||
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