2-MPPA
| CAS No. | 254737-29-6 | Cat. No. | BCP29740 |
| Name | 2-MPPA | ||
| Synonyms | 2-(3-mercaptopropyl)pentanedioic acid;2-(3-sulfanylpropyl)pentanedioic acid; | ||
| Formula | C8H14O4S | M. Wt | 206.26 |
| Description | 2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM). Selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. Antinociceptive in a rat model of neuropathic pain and protects against motor neuron death in familial amyotrophic lateral sclerosis mice. Orally bioavailable. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Carboxypeptidase | ||
Structure
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