2-MPPA
Data Sheet
For research use only. Not for human use.
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| CAS No. | 254737-29-6 | Cat. No. | BCP29740 |
| Name | 2-MPPA | ||
| Synonyms | 2-(3-mercaptopropyl)pentanedioic acid;2-(3-sulfanylpropyl)pentanedioic acid; | ||
| SMILES | C(CC(CCC(=O)O)C(=O)O)CS | ||
| Chemical Name | |||
| Formula | C8H14O4S | M. Wt | 206.26 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | 2-MPPA is a selective glutamate carboxypeptidase II (GCP II) inhibitor (IC50 = 90 nM). Selective for GCP II over NMDA, kainate and AMPA glutamate receptors and MMP-1, -2, -3, -7, -9, ACE and NEP metalloproteases. Antinociceptive in a rat model of neuropathic pain and protects against motor neuron death in familial amyotrophic lateral sclerosis mice. Orally bioavailable. | ||
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